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GRK 1482 Jahrbuch 2011-2014

SENIOR PRINCIPAL INVESTIGATORS Page 16 | GRK Progress Report 2011-2014 Education / Degrees 1990 -1997 Food Technology, University of Hohenheim 1993 - 1996 Nutrition Science, University of Hohenheim 1996 Diploma in Nutrition Science ’summa cum laude’ 1997 Diploma in Food Technology ’summa cum laude’ 1999 Ph.D. in Microbiology and Immunology ’summa cum laude’ ’Modulation of the immune response by non-pathogenic bacteria’ Positions held 1999-2000 Scientist at the Nestlé Research Center in Lausanne/Switzerland, Department of Immunology 2001-2002 DFG Emmy Noether research fellow of excellence at the University of North Carolina/USA, Department of Medicine 2003-2006 DFG Emmy Noether group leader of excellence at Technische Universität München 2005 Declined Associate Professorship at University of Alberta, Canada, Department of Medicine 2006-2008 Associate Professor (W2) at Technische Universität München, Experimental Nutritional Medicine 2007 Declined Full Professorship at ETH Zürich, Switzerland Nutritional Biochemistry (Chair) 2007 to date Head of Department 2008 to date Full Professor (W3) at Technische Universität München Research Interests and Achievements The main areas of research relate to the understanding of nutrition and the intestinal microbiome in the initiation, prevention and therapy of chro- nic inflammatory diseases of the intestinal tract.a Nutritional factors such as iron or gluten affect the complex microbial ecosystem and host res- ponses. Mechanisms of microbe-host interactions are characterized by the use of conventional and gnotobiotic mouse models for inflammatory bowel diseases (IBD). A major focus is the identification of specific micro- bial structures relevant for the initiation and prevention of intestinal inflam- mation targeting pathobionts or probiotics. Epithelial cells provide a primary interface for the microbial ecosystem and are therefore of key interest to understand mechanisms of microbe-host interactions in the intestine. Unfolded protein responses (UPR) related to endoplasmic reticulum and mitochondrial stress are important biological functions of the epithelium to maintain structural homeostasis of the intestinal tissue. In this context, the use of novel organ-specific mouse models will help to characterize the role of UPR in the context of tissue repair and inflammatory processes as well as tumorigenesis. Major achievements are the scientific coordination of a Priority Grant of the German Research Foundation (DFG) and a Forward Look Initiative of the European Science Foundation (ESF). Prof. Dr. Dirk Haller Technische Universität München Nutrition and Immunology (Chair) Gregor-Mendel-Str. 2, D-85350 Freising-Weihenstephan Selected Publications Von Schillde M-A, Hörmannsperger G, ..., Haller D. Lactocepin secreted by Lactobacillus exerts anti- inflammatory effects by selectively degrading pro-inflammatory chemokines. Cell Host Micro- be 2012;11(4):387-96. Rath E, ..., Haller D. Induction of dsRNA-activated protein kinase links mitochondrial unfolded pro- tein response to the pathogenesis of intestinal inflammation. Gut 2012;61(9):1269-78. Chang J-S, ..., Haller D. Endoplasmic reticulum stress response promotes cytotoxic phenotype of CD8αβ+ intraepithelial lymphocytes in a mouse model for Crohn´s disease-like ileitis. J Immunol. 2012;189(3):1510-20. Renz H, von Mutius E, Brandtzaeg P, Cookson W, Autenrieth I, Haller D. Gene environment interac- tion in chronic inflammatory disease. Nat. Immu- nol. 2011;(4):273-277. Steck N, ..., Haller D. Enterococcus faecalis Metalloprotease Compromises Epithelial Barri- er and Contributes to Intestinal Inflammation. Gastroenterology 2011;141(3):959-71. Research Goals Impact of nutritional factors on the compo- sition and function of the intestinal micro- biome Characterization of microbe-host interac- tions under conditions of chronic intestinal inflammation Functional role of the unfolded protein res- ponse (UPR) in inflammation and tumorige- nesis