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GRK 1482 Jahrbuch 2011-2014

SENIOR PRINCIPAL INVESTIGATORS GRK Annual Report 2011-2014 | Page 17 Education / Degrees 1975 - 1981 Medical Schools of the University of Regensburg and the Technical University of Munich 1981 Degree of Medical Doctor 1978 - 1980 Medical Thesis at the Institute for Diabetes Research at the City Hospital Munich-Schwabing 1982 Official thesis at the Ludwigs-Maximilians-University of Munich Positions held 1982 - 1983 PostDoc Training at the Institute of Biochemistry, Microbio logy and Genetics of the University of Regensburg 1984 - 1989 Internship at the Department of Internal Medicine (Division of Endocrinology and Metabolism) of the University of Ulm 1989 Senior Consultant of the Clinical Department of the German Diabetes Research Institute at the Heinrich-Heine-University of Düsseldorf 1990 Habilitation in Internal Medicine 1991 Subspeciality Endocrinology 1995 Associate Professor at the Heinrich-Heine-University of Düsseldorf 1997 Deputy Head of the Clinical Department of the German Diabetes Research Institute Since 2003 Chair of Nutritional Medicine at TU Munich Research Interests and Achievements The research interests of the chair are: • Adipose tissue biology to better understand the mechanisms explaining the complications of obesity. These activities are focussing on the func- tional changes associated with fat cell hypertrophy including the role of inflammation and insulin resistance • functional characterization of obesity- and type 2 diabetes-associated risk loci identified in recent GWAs. These studies include in vitro charac- terization of SNPs as well as phenotyping of subjects carrying specific risk alleles of interest • studies on the heterogeneity of the metabolomic response of humans to specific test meals and other environmental challenges • dietary and lifestyle intervention during pregnancy for the primary preven- tion of obesity in children including long-term follow-up of the mothers and their offspring with specific focus on body fat mass (INFAT Study and GeLiS Study) • effect of lifestyle intervention in women with breast cancer on long-term prognosis of the disease (SUCCESS-C-Study) Prof. Dr. Hans Hauner Technische Universität München Nutritional Medicine (Chair) Gregor-Mendel-Str. 2, D-85350 Freising-Weihenstephan Selected Publications Hauner H, Much D, Vollhardt C, Brunner S, Schmid D, Seldmeier E-M, Heimberg E, Schuster T, Zimmermann A, Schneider KTM, Bader BL, Amann-Gassner U, Hauner H: Reducing the n-6/n-3 long-chain polyunsaturated fatty acid (LCPUFA) ratio during pregnancy and lactation does not affect adipose tissue growth in the off- spring in the first year of life: an open-label ran- domized controlled trail. Am J Clin Nutr 2012, 95:383-394. Brunner S, Holub I, Theis S, Gostner A, Melcher R, Wolf P, Amann-Gassner U, Scheppach W, Hauner H: Low glycemic dietary modulation re- placing sucrose in sweet foods and beverages on metabolic control in subjects with type 2 diabe- tes – a randomized controlled trial. Diabetes Care 2012, 35:1249-1251. Jebb S, Ahern AL, Olson AE, Aston LA, Holzapfel C, Stoll J, Amann-Gassner U, Simpson AE, Fuller NR, Pearson S, Lau NS, Mander AP, Caterson IA, Hauner H: Primary Care referral to a commer- cial provider for weight loss treatment relative to standard care: an international randomised cont- rolled trial. Lancet 2011, 378:1225-1231. Research Goals To better understand adipose tissue physio- logy in the context of overnutrition and obesity To understand the functional role of diabe- tes risk loci and to develop better strategies for early prediction and prevention of type 2 diabetes To prevent childhood obesity by early intervention in pregnancy and lactation and to elucidate the lifestyle factors leading to „mal-programming“ of the infants