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GRK 1482 Jahrbuch 2011-2014

SENIOR PRINCIPAL INVESTIGATORS GRK Annual Report 2011-2014 | Page 19 Education / Degrees 1991 - 1999 Medical School, Ludwig-Maximilians-Universität, Munich, Germany 2000 Medical Thesis, Department of Clinical Pharmacology, Ludwig-Maximilians-Universität, Munich 2001 Medical Practice License 2008 Habilitation and venia legendi for Internal Medicine, Technische Universität München 2010 Specialist in Internal Medicine – board examination Positions held 1999 - 2001 Postdoctoral Scientist, Department of Clinical Pharmaco- logy, Ludwig-Maximilians-Universität, Munich 2001 - 2003 Postdoctoral Scientist, Department of Pathology and Immunology, Washington University St. Louis, USA (Prof. Marco Colonna) 2004 to date Group leader and fellow in Internal Medicine/ Gastroentero- logy, II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universtität München Research Interests and Achievements The group of Anne Krug studies dendritic cell biology in the context of im- mune defense and inflammatory diseases with a focus on chronic intesti- nal inflammation. Dendritic cell (DC) and macrophage subpopulations fulfill distinct functions in the immune system and are highly potent immune cells which trigger innate and adaptive responses. The in vivo function of DC subpopulations is studied in the mouse model in the steady state as well as in inflammatory diseases and viral infections. It was previously shown that antigen targeting to specific DC subsets such as plasmacytoid DC (pDC) in vivo can be designed to generate effective immunity or antigen-specific immune tolerance. Recently, it was found that pDC develop from a pDC- biased circulating precursor, which develops into pDC or conventional DC subsets depending on the tissue-specific microenvironment which modu- lates the expression of key transcription factors. Thus, the local micromilieu such as in the intestine for example, is ciritical for final differentiation of DC-committed precursors into functionally distinct DC subpopulations. In two models of inflammatory bowel disase it was shown that a DC-specific chemokine CCL17 acts in an autocrine manner on intestinal DCs to pro- mote proinflammatory cytokine production inducing Th1/Th17 responses while suppressing regulatory T cells thus promoting colitis development. Currently the impact of external factors such as diet components on intes- tinal DCs/ macrophages are studied. PD Dr. Anne Krug Technische Universität München Klinikum rechts der Isar | Internal Medicine II Ismaninger Str. 22, D-81675 Munich Selected Publications Krug A. et al. Colonna M. TLR9-dependent reco- gnition of MCMV by IPC and DC generates coor- dinated cytokine responses that activate antiviral NK cell function. Immunity. 2004, 21:107-19. Rad R. et al. Krug A. Extra- and Intracellular pat- tern recognition receptors cooperate in the reco- gnition of Helicobacter pylori. Gastroenterology. 2009, 136:2247-57. Loschko J., Heink S. et al. Krug A. Antigen targe- ting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity. The Journal of Immunology. 2011, 187:6346-56. Schlitzer A. et al. Krug A. Tissue-specific dif- ferentiation of a circulating CCR9- pDC-like common dendritic cell precursor. Blood. 2012, 119(25):6063-71. Heiseke A. F. et al. Krug A.*, Reindl W.* CCL17 drives intestinal inflammation and counteracts regulatory T cell mediated protection from colitis in mice. Gastroenterology. 2012, 142:335-45. Research Goals To gain insight into the functional diversity of intestinal dendritic cell and macrophage subpopulations To understand tissue-specific dendritic cell development and plasticity To develop DC-specific antigen targeting strategies for in vivo manipulation of immune responses To investigate the role of DC subpopula- tions and DC-specific molecules in intestinal inflammation