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GRK 1482 Jahrbuch 2011-2014

SENIOR PRINCIPAL INVESTIGATORS Page 20 | GRK Progress Report 2011-2014 Education / Degrees 1979 - 1984 Study of Biology at Technische Universität München, Germany 1984 Diploma in Biology (Major in Microbiology) 1986 Ph.D. (Protein secretion in staphylococci) summa cum laude, Technische Universität München 1997 Habilitation and venia legendi for Microbiology (Faculty of Chemistry, Biology and Geosciences, Technische Universität München) Positions held 1986 - 1987 Postdoctoral fellow, Massachusetts Institute of Technology (M.I.T.), Cambridge, USA (research stipendium from DFG) 1988 - 1997 Akad. Rat and akad. ORat at Department of Microbiology, TU München 1997 - 2003 Associate Professor of Applied Microbiology (C3), Univ. Göttingen 2002 - 2004 Dean and Vice Dean of Biological Faculty, Univ. Göttingen 2003 - 2008 Full Professor of Microbiology (C4), Head of Department of Genomic and Applied Microbiology, Universität Göttingen 2008 to date Full Professor (Ordinarius) of Microbiology (W3), head of Department of Microbiology, TU München 2010 to date Dean of Study Affairs for Biological Sciences, TU München Research Interests and Achievements As merely a small fraction of the microorganisms present in nature are cul- tivated to date and therefore a huge metabolic diversity remains unexplored and untapped for application, we are interested in the microbial and enzy- matic diversity in various habitats. To this end, we develop and apply mole- cular methods for the identification and visualization of different microbial taxa, and use metagenomic approaches for the characterization of micro- bial communities, including the use of new cloning and expression hosts for metagenomic library screening. We also have a deep interest in the analysis of bacteria and archaea adap- ted to extremes of temperature and ph and their enzymology involved in the utilization of polysaccharides. We were able to characterize various en- zymes with unusual catalytic properties, and have studied novel cellulose- and xylan-binding modules (CBMs) representing new CBM families. Also, we have determined and interpreted the genome sequence information from various microbes, including e.g. the cellulose-degrading thermophiles Spirochaeta thermophila and Clostridium stercorarium, or the thermophilic hyperacidophile Picrophilus torridus, an archaeum able to grow at around pH 0. Finally, we are interested in the physiology and genetics, and the ge- nomic and metabolic engineering of biotechnologically relevant bacteria (acetic acid bacteria, clostridia, bacilli and actinobacteria). Prof. Dr. Wolfgang Liebl Technische Universität München Microbiology (Chair) Emil-Ramann-Str. 4, D-85350 Freising-Weihenstephan Selected Publications Poehlein A, Zverlov V, Daniel R, Schwarz W, Liebl W. Complete genome sequence of Clost- ridium stercorarium DSM 8532, a thermophilic degrader of plant cell wall fibres. genomeA. 2013, 1:e00073-13. Thürmer A, Voigt B, Angelov A, Hecker M, Liebl W. Proteomic analysis of the extreme thermoacido- philic archaeon Picrophilis torridus during growth at pH and temperature values close to its growth limit. Proteomics. 2011, 11:4559-4568. Köpke M, Held C, Hujer S, Liesegang H, Wiezer A, Wollherr A, Ehrenreich A, Liebl W, Gottschalk G, Dürre P. Clostridium ljungdahlii represents a microbial production platform based on syngas. Proc Natl Acad Sci USA. 2010, 107:13087-13092. Voss J, Ehrenreich A, Liebl W. Characterization and inactivation of the membrane-bound polyol dehydrogenase in Gluconobacter oxydans DSM 7145 reveals a role in meso-erythritol oxidation. Microbiology. 2010, 156:1890-1899. Angelov A, Mientus M, Liebl S, Liebl W. A two-host fosmid system for functional screening of (meta) genomic libraries from extreme thermophiles. Sys Appl Microbiol. 2009, 32:177-185. Research Goals To achieve a better understanding of micro- bial adaptation to extreme conditions To investigate microbial and enzymatic diversity, in particular related to carbohydra- te utilization, by (meta)genome analysis of isolated microorganism and microbial con- sortia To characterize and improve selected bio- technologically relevant bacteria by genomic and metabolic engineering