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GRK 1482 Jahrbuch 2011-2014

SENIOR PRINCIPAL INVESTIGATORS Page 24 | GRK Progress Report 2011-2014 PD Dr. Thomas Skurk Technische Universität München Nutritional Medicine Gregor-Mendel-Str. 2, D-85350 Freising - Weihenstephan Education / Degrees 1991 - 1998 Medical studies in Regensburg and Würzburg 1994 - 1998 Doctoral thesis in Regensburg (Professor Dr. G. Löffler, Chair for Biochemistry III, Institute for Biochemistry, Genetics and Microbiology) 1998 – 2003 Internship in Internal Medicine/Diabetology and PostDoc at the German Diabetes Center, Leibniz Institute at the Heinrich- Heine-University Düsseldorf 2010 Habilitation and venia legendi for Nutritional Medicine, Technische Universität München Positions held 1998 - 2003 Assistant physician and research associate, German Diabetes Center, Leibniz Institute at the Heinrich-Heine-University Düsseldorf 2003 - 2010 Senior scientist and coordinator of the Human Study Center (HSC), Chair for Nutritional Medicine, Technische Universität München 2010 to date Research Assoc. & Assistant professor, Technische Universität München (TUM), Germany, Else Kröner-Fresenius-Center for Nutritional Medicine, Chair for Nutritional Medicine Research Interests and Achievements Nutrition accompanies us throughout life time. Nowadays, diet associated comorbidities can cause diseases with a negative socioeconomic impact. Diabetes mellitus is one of the most prevalent chronic disease in developed countries especially in the elderly and it is the most expensive. Of disease promoting relevance is the development of overweight and obesity accom- panied by a significant increase of adipose tissue mass. The growth pat- tern is hereby of importance as the generation of large, hypertrophic cells is considered to cause a low-grade chronic inflammatory state which can be measured in the plasma and can be commonly observed in obese sub- jects. However, the precise origin of this inflammation is not yet known, but the transformation of adipocytes into pro-inflammatory fat cells is sugges- ted to be pathophysiologically relevant in this context. Enlargement of adi- pocytes brings about the risk to secrete a dysregulated cytokine pattern favouring pro-inflammatory adipokines. The question which appears and will be addressed in this graduate school is to identify those soluble factors which are able to influence the secretory pattern of L-cells in the gastrointes- tinal tract. These cells are able to serete GLP-1, which is the most important nutrient dependent factor to promote insulin secretion. Some candidates from the adipokine pool seem of greater importance than others. A clini- cal study will accompany in vitro research to unravel mechanisms causing dysglycaemic conditions like insulin resistance or type 2 diabetes mellitus. Selected Publications Kunert C, Skurk T, Frank O, Lang R, Hauner H, Hof- mann T. Development and application of a stab- le isotope dilution analysis for the quantitation of advanced glycation end products of creatinine in biofluids of type 2 diabetic patients and healthy volunteers. Anal Chem. 2013, 85(5): 2961-9. Lubinus T, Barnsteiner A, Skurk T, Hauner H, Engel KH. Fate of dietary phytosteryl/-stanyl esters: analysis of individual intact esters in human feces. Eur J Nutr. H 2013, 52:997-1013. Krug S, Kastenmüller G, Stückler F, Rist MJ, Skurk T, Sailer M et al. The dynamic range of the human metabolome revealed by challenges. FASEB J. 2012, 26:2607-2619. Laurencikiene J, Skurk T, Kulyté A, Hedén P, Aström G, Sjölin E, Rydén M, Hauner H, Arner P. Regulation of lipolysis in small and large fat cells of the same subject. J Clin Endocrinol Metab. 2011,96:E2045-2049. Arner P, Bernard S, Salehpour M, Possnert G, Liebl J, Steier P, Buchholz BA, Eriksson M, Skurk T, et al. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature. 2011, 478:110-3. Research Goals Developmental aspects of adipose tissue in the context of obestiy associated co-morbi- dities with respect to diabetes or athero- sclerosis Pathophysiologically relevant mechanisms to detect and prevent diet associated co- morbidities Metabolic phenotyping to foster the deve- lopment of individualized nutritional recom- mendations Clinical studies on the nutritional value of food and defined food constituens