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GRK 1482 Jahrbuch 2011-2014

FOREWORD | WELCOME TO THE GRK 1482 Page 4 | GRK Progress Report 2011-2014 Welcome to the GRK 1482 The GRK 1482 brings together a unique spectrum of experts from nutrition, microbiology and physiology as well as medical sciences to understand the role of the gut interface in health and disease states. We are proud to announce the successful renewal of our Research TrainingGroup GRK 1482 entitled “Interface func- tions of the intestine between luminal factors and host signals” starting with the 2nd funding phase on October 1, 2012. The DFG financially supports the GRK 1482 with almost 2.8 Million Euro for another 4.5 years. It is my great pleasure, also in the name of the deputy spokesperson Prof. Dr. Martin Klingenspor, to welcome our 15 new PhD fellows and all partici- pating PIs. We enthusiastically welcome Dorothea Wörner who is not only responsible for the administrative organization but rather represents the good soul of our GRK 1482. The intestinal tract acts as an important barrier and communi- cation organ at the interface between the luminal environment, including nutritional and microbial factors, and the host. Signals derived from this interplay are transmitted through epithelial, immune, neuronal and hormonal networks and affect intestinal functions as well as peripheral tissues of the host. Inflammatory processes play a particular role in shaping these interactions towards a disease susceptible milieu that favors the deve- lopment of chronic disorders including inflammatory bowel diseases (IBD) and obesity-driven metabolic dysregulation. Supported by our findings from the first funding period, the scientificfocusofGRK1482willfurtherhighlighttheintestineasa bidirectional communication organ to better understand the interplay of luminal and subepithelial/peripheral signals at this critical interface. Based on a critical review and quality-guided evaluation process of the 1st funding period we selected 15 research projects to be continued by the 2nd generation of PhD fellows. The 2nd phase of the GRK funding period will be used to shape the already visible scientific core expertise based on establis- hed interactions between the different Principal Investigators (PIs) and common projects at TUM providing the scientific and human resource nucleus for the future work. Art includes everything that stimulates the desire to live; science, everything that sharpens the desire to know. Rémy de Gourmont Foreword Last year we defended our Research Training Grant of the Deut- sche Forschungsgemeinschaft (DFG) in a very competitive evaluation procedure with great success. PhD fellows and PIs in a truly joint effort convinced the critical minds of the revie- wer panel that the research and education environment of the Graduiertenkolleg (GRK) 1482 provides a lively and skilled plat- form for scientific and personal development. This success was not only a matter of numbers but was also the consequence of a collaborative spirit … for this effort I want to express my great gratitude. We are facing 4.5 more years and have the pleasure to guide and educate two future generations of PhD fellows. We should be aware that the process of mentoring and learning is based on the partnership of all participants which will again require a lot of enthusiasm, time and engagement to foster the scientific spirit. This is the MIDTERM Report of GRK 1482 covering a short sum- mary of the 1st funding period, an introduction of the respon- sible PIs and the 2nd generation of PhD fellows as well as their projects, and finally the program of our first Science Camp. This meeting will take place at an inspiring location of the Monastery Seeon thematically covering all important research areas of GRK 1482. We invited key note speakers with an international reputation for Microbiota and Diet, Gut as Interface, and Meta- bolism. We also invited PhD fellows from Wageningen University as well as University of Sao Paulo to present together with our PhD fellows their work. This international environment should create a viable platform with an inspiring atmosphere for dis- cussions and critical feedback. I am looking forward to fruitful discussions and good science … let’s all sharpen the desire to know! Prof. Dr. Dirk Haller Spokesperson GRK 1482 Foreword | Welcome to the GRK 1482